Dr. Wang is currently working as Assistant Professor at the
Department of Internal Medicine of E-Da Hospital in Taiwan. His expertise is in
therapeutic and diagnostic endoscopy. He was graduated from National Taiwan
University, and received medical training at the National Taiwan University
Hospital. In 2015, he got the Ph.D. degree from the Institute of Clinical
Medicine at National Cheng Kung University. His research activities focus on
early gastrointestinal neoplasia, field cancerization over the upper
aerodigestive tract, image-enhanced endoscopy, endoscopic submucosal dissection
(ESD), and Radiofrequency ablation (RFA)
1. Wang WL, Lee CT, Lee YC, Hwang TZ,
Wang CC, Hwang JC, Tai CM, Chang CY, Tsai SS, Wang CP, Ko JY, Lin JT. Risk
factors for developing synchronous esophageal neoplasia in patients with head
and neck cancer. Head & neck 33(1): 77-81, 2011
發現頭頸癌患者有高比率(20%)會同時發生食道癌，及其好發的危險因子；本篇論文也被國內外耳鼻喉科醫學會所引用，改變了過去頭頸癌的分期及治療方針。
2. Wang WL, Wang CP, Wang HP, Lee CT,
Chang CY, Tai CM, Tseng CH, Hwang TZ, Wang CC, Lo JL, Tseng PH, Chiu HM, Lee
JM, Ko JY, Lou PJ, Wu MS, Lee YC, Lin JT. The benefit of pretreatment
esophageal screening with image-enhanced endoscopy on the survival of patients
with hypopharyngeal cancer. Oral oncology 49(8): 808-13, 2013
本篇論文提供針對下咽癌患者進行常規食道內視鏡篩檢可以改善患者存活率的佐證,改變了過去頭頸癌的治療方針。
3. Wang WL, Chang WL, Yeh YC, Lee CT,
Chang CY, Lin JT, Sheu BS. Concomitantly elevated serum matrix
metalloproteinases 3 and 9 can predict survival of synchronous squamous cell
carcinoma of the upper aero-digestive tract. Molecular carcinogenesis 52(6):
438-45, 2013
臨床上很難評估發食道癌及頭頸癌患者的存活率，本研究首次發現同時併發食道癌及頭頸癌患者的臨床預後指標。
4. Wang WL, Chang IW, Chang CY, Lin JT,
Mo LR, Wang HP, Lee CT. Circumferential balloon-based radiofrequency ablation
for ultralong and extensive flat esophageal squamous neoplasia.
Gastrointestinal endoscopy 80(6): 1185-9, 2014
本研究首創利用RFA治療超長廣泛性的食道病變，明顯減少患者過去利用手術或內視鏡黏膜下剝離術治療的併發症。
5. Wang WL, Wang YC, Lee CT, Chang CY,
Lo JL, Hsu YC, Mo LR. The impact of human papillomavirus infection on the
survival and treatment response of patients with esophageal cancers. Journal of
digestive diseases 16(5): 256-63, 2015
探討人類乳突病毒(HPV)在食道癌的角色，結果發現國人食道癌患者約18%有HPV感染，尤其是第16型，且有感染的患者對電放療的反應較佳。
6. Wang WL, Chang WL, Yang HB, Chang IW,
Lee CT, Chang CY, Lin JT, Sheu BS. Quantification of tumor infiltrating Foxp3+
regulatory T cells enables the identification of high-risk patients for
developing synchronous cancers over upper aerodigestive tract. Oral oncology
51(7): 698-703, 2015
第一篇研究發現宿主免疫缺陷可能導致多發性腫瘤(區域致癌現象)之產生。
7. Wang WL, Chang IW, Chen CC, Chang CY,
Lin JT, Mo LR, Wang HP, Lee CT. Radiofrequency ablation versus endoscopic
submucosal dissection in treating large early esophageal squamous cell
neoplasia. Medicine (Baltimore) 94(49):e2240, 2015
第一篇原創研究直接比較ESD和RFA在治療早期食道癌的優缺點。
8. Wang WL, Wang YC, Chang CY, Lo JL,
Kuo YH, Hwang TZ, Wang CC, Mo LR, Lin JT, Lee CT. Human papillomavirus
infection on initiating synchronous esophageal neoplasia in patients with head
and neck cancer. The Laryngoscope 126(5):1097-102, 2016
探討人類乳突病毒(HPV)是否為食道癌、頭頸部癌等多發性腫瘤及區域致癌現象的致病因子。
9. Wang WL, Chang IW, Chen CC, Chang WL,
Chu YY, Wu PH, Tai WC, Chen PY, Hsieh PH, Chung CS, Chang CY, Lin JT, Wang HP,
Lee CT. Predictors for postoperative esophageal stricture after balloon-based
radiofrequency ablation for early esophageal squamous neoplasia ~A multicenter
validation study. Therapeutic Advances in Gastroenterology 9 (3):257-64, 2016
深入分析以RFA治療早期食道癌後，產生食道狹窄的風險因子，結果發現食道狹窄的產生和病變治療的長度有相關。
10. Wang WL, Chang IW, Chen CC, Chang
CY, Lin JT, Mo LR, Wang HP, Lee CT. The spatial predilection for early
esophageal squamous cell neoplasia~ a “hot zone” for endoscopic screening and
surveillance. Medicine (Baltimore) 95(15):e3311, 2016
早期食道癌篩檢不易，本研究探討早期食道癌是否有好發的熱區，針對此熱區應該仔細檢查。
11. Wang WL, Chang WL, Yang HB, Wang YC,
Chang IW, Lee CT, Chang CY, Lin JT, Sheu BS. Low Disabled-2 expression promotes
tumor progression and determines poor survival and high recurrence of
esophageal squamous cell carcinoma. Oncotarget
7 (44): 71169-71181, 2016
結合基礎與臨床研究,發現食道癌患者的臨床腫瘤標記。
12. Wang WL, Chang IW, Chen CC, Chang
CY, Mo LR, Lin JT, Wang HP, Lee CT. A case series on the use of circumferential
radiofrequency ablation for early esophageal squamous neoplasias in patients
with esophageal varices. Gastrointestinal endoscopy 85 (2): 322-329, 2017
首次評估RFA使用在同時患有早期食道癌及食道靜脈瘤患者的效益及安全性，提供肝硬化患者罹患食道癌時治療的新選擇。
